Study Overview

The Hispanic Community Health Study / Study of Latinos (HCHS/SOL) is a multi-center epidemiologic study in Hispanic/Latino populations to determine the role of acculturation in the prevalence and development of disease, and to identify risk factors playing a protective or harmful role in Hispanics/Latinos. The study is sponsored by the National Heart, Lung, and Blood Institute (NHLBI) and six other institutes, centers, and offices of the National Institutes of Health (NIH) contributed to the first phase of the project.
Study goals include studying the prevalence and development of disease in Hispanics/Latinos, the role of acculturation, and to identify risk factors that play protective or harmful roles in Hispanics/Latinos. The target population of 16,000 persons of Hispanic/Latino origin, specifically Cuban, Puerto Rican, Mexican, and Central/South American, to be recruited through four Field Centers affiliated with San Diego State University, Northwestern University in Chicago, Albert Einstein College of Medicine in the Bronx area of New York, and the University of Miami. Seven additional academic centers serve as scientific and logistical support centers.
Study participants aged 18-74 years underwent an extensive clinic exam and assessments to determine baseline risk factors. Annual follow-up interviews will be conducted for 2-4 years to determine health outcomes of interest. Study results will be disseminated through scientific journals and also conveyed to the communities involved in the study in order to improve public health at the local level.
In February 2014, the NIH presented a summary of medical research results of the Hispanic Community Health Study/Study of Latinos to the communities and participants from the largest health study of Hispanic/Latino populations in the United States. This report provides data from the first examination of participants who attended the study. It highlights health areas that are having a positive impact in these communities and those that need greater attention to improve lives.
Visit 2 is underway with second clinic visits for all of the original participants. Additionally, a number of funded ancillary studies are enrolling in the original cohort.  In addition to the peer reviewed published manuscripts HCHS/SOL Investigators periodically produce lay summaries of findings appropriate for the participants, these fact sheets are posted on the participant webstie (link on the links page).
The Genetic Analysis Center (GAC) at the University of Washington, Seattle is the working arm of the Genetic Studies Committee (GSC) of HCHS/SOL.  The Genetic Analysis Center performed genotypic data cleaning on genome-wide SNP microarray data for approximately 13,000 subjects for HCHS/SOL. The cleaned data, quality metrics and quality control report will be used for downstream analyses and posted on the Database of Genotypes and Phenotypes (dbGaP), which is housed at the National Center for Biotechnology Information (NCBI).  The GAC provides statistical support to the HCHS/SOL genetic working groups that will publish papers focusing on risk factors and traits of interest for specific conditions.  The NHLBI program officials facilitate the achievement of scientific goals and provide institutional oversight and guidance to the project.