Studies

Project Name Clinical Centers / Central Agencies Participants Study Design Beginning Ending Funding Agency
A Comparison of Long-Acting Injectable Medications for Schizophrenia (ACLAIMS) 25
  • 360
  • Randomized, double-masked comparative effectiveness clinical trial
2009 2014 Columbia Univ / NIMH
ARIC MRI and Neurocognitive Longitudinal Study (ARICMRI) 2
  • 1,134
  • Prospective cohort follow-up
2002 2008 NHLBI
ARIC Neurocognitive Study (ARIC NCS) 4
  • 8,600
  • Observational study
2010 2019 NHLBI
Asymptomatic Carotid Atherosclerosis Study (ACAS) 37
  • 1,500
  • Randomized, unmasked trial
1987 1998
Atherosclerosis Risk in Communities (ARIC) 4
  • 16,000
  • Prospective cohort follow-up
1985 2016 NHLBI
Bronchiectasis Research Registry (BRON) 11
  • Patient Registry
2007 2014 COPD Foundation
Carotid MRI (CARMRI) 4
  • 2,066
  • Cross-sectional and prospective design
2004 2009 NHLBI
Cholesterol Reduction in Seniors Program (CRISP) 5
  • 400
  • Randomized, double-masked pilot study
1990 1992 NHLBI
Combining Medications and Behavioral Interventions (COMBINE) 11
  • 1,380
  • Randomized 2x2x2 factorial trial
1997 2007 NIAAA
Comparison of Antipsychotics for Metabolic Problems (CAMP) 26
  • 300
  • Randomized, open-label placebo-controlled clinical trial
2006 2011 NHLBI
Comparison of Depression Interventions after Acute Coronary Syndrome (CODIACS) 5
  • 150
  • Randomized, single-masked clinical trial
2009 2011 NHLBI
Comparison of Optimal Antipsychotic Treatments for Schizophrenia (COATS) 15
  • 90
  • Randomized, open-label clinical trial
2008 2011 NIMH
Dietary Effects on Lipoproteins and Thrombotic Activity (DELTA) 4
  • 200
  • 2 Randomized, double-masked trials
1992 1996 NHLBI
Enhancing Recovery in Coronary Heart Disease (ENRICHD) 8
  • 2,481
  • Randomized, unmasked trial
1995 2005 NHLBI
Epidemiologic Studies of Glargine Use and Cancer Risk (DIMS-ESGUCR )
  • Multi-site retropspective study
2009 2013 Sanofi-aventis
Fluvastatin Registration Program (FRP) 68
  • 2,000
  • 7 Randomized, double-masked trials, open-label safety study
1988 1991
Hispanic Community Health Study / Study of Latinos (HCHS/SOL) 4
  • 16,000
  • Population-based prospective cohort follow-up
2006 2019 NHLBI
Hispanic Community Health Study / Study of Latinos Youth Study (HCHS/SOL) 4
  • 1,600
  • Cross-sectional observational study
2011 2014 NHLBI
International Studies of CVD (INTL) 7
  • 20,000
  • 4 prospective cohort follow-up,<br>randomized, unmasked trials
1990 2000 NHLBI
Jackson Heart Study Advisory Coordinating Center (JHS) 1
  • 6,500
  • Prospective cohort follow-up, family genetic study
1999 2018 NHLBI
Laser Induced, Biologically Engineered Remodeling of Thermally Injured Skin Trial (LIBERTI) 2013 2017
Lipid Research Clinics Program (LRC) 16
  • 81,000
  • 14,000
  • 3,800
  • 18,000
  • Prevalence Study
  • Prospective cohort follow-up
  • Randomized, double-masked trial
  • Family genetics study
1971 1990 NHLBI
Longitudinal Studies of Child Abuse and Neglect (LONGSCAN) 5
  • 1,400
  • Prospective cohort follow-up
1991 2011 NCCAN
Maternal Oral Therapy to Reduce Obstetric Risk (MOTOR) 3
  • 1,800
  • Randomized, unmasked trial
2003 2009 NIDCR
Metformin in Treatment of Antipsychotic-Induced Weight Gain in Schizophrenia (METS) 17
  • 80
  • Randomized, double-masked placebo-controlled trial
2008 2010 NIMH
MOTOR Kids (MOTOR KIDS) 3
  • 332
  • Observational study
2006 2011 NIDCR
National Strategy for Environment and Health, United Arab Emirates (UAEE)
  • 600
  • Population survey
2008 2012 Environmental Agency - Abu Dhabi
Obesity Prevention in Native American Indians (PATHWAYS) 4
  • 1,700
  • Community randomized, single-masked trial
1993 2004 NHLBI
PeRiodontal treatment to Eliminate Minority InEquality and Rural disparities in Stroke (PREMIERS) 2015 2019
Periodontitis and Vascular Events (PAVE) 5
  • 300
  • Randomized pilot study
2001 2006 University of Buffalo
Predicting Responses to Standardized Pediatric Colitis Therapy (PROTECT) 24
  • 430
  • Multicenter open-label clinical trial
2012 2017 Univ Connecticut / NIDDK
Randomized Intervention in Children with VesicoUreteral Reflux (RIVUR) 15
  • 600
  • Randomized, double-masked controlled clinical trial
2005 2015 NIDDK
Studies of Left Ventricular Dysfunction (SOLVD) 28
  • 6,300
  • 2 Randomized, double-masked trials
1985 1993 NHLBI
Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) 6
  • 3,200
  • Observational study
2009 2018 NHLBI
Trial of Activity for Adolescent Girls (TAAG) 6
  • 10,000
  • 2-arm group randomized trial
2000 2009 NHLBI
Trial of Surgery & Thrombolysis in Ischemia of the Lower Extremity (STILE) 34
  • 400
  • Randomized, unmasked trial
1991 1994 NHLBI
Vitamin Intervention for Stroke Prevention (VISP) 56
  • 3,600
  • Randomized, double-masked trial
1996 2008 NHLBI
Women's Health Initiative (WHI)
  • 4,700
  • Observational study and clinical trials
2011 2021 Fred Hutchinson Cancer Inst. / NHLBI