|Title||Data needs for cancer comparative effectiveness research, and the Integrated Cancer Information and Surveillance System|
|Year of Publication||2012|
|Authors||Carpenter, William R.|
Randomized controlled trials (RCTs) remain the gold standard for evaluating cancer intervention efficacy, though are not always feasible, practical, or timely, and often don’t adequately reflect patient heterogeneity and real-world clinical practice. Comparative effectiveness research can leverage secondary data to help fill knowledge gaps RCTs leave unaddressed; however, comparative effectiveness research also faces shortcomings. We discuss the development of a new model that informs an evolving framework articulating cancer comparative effectiveness research data needs. We present it in the context of the Integrated Cancer Information and Surveillance System (ICISS), a University of North Carolina initiative to develop a large linked-data computing system to support cancer-focused comparative effectiveness and outcomes research.