|Title||DiNAMIC: Discovering copy number aberrations manifested in cancer (R).|
|Year of Publication||2011|
|Authors||Walter, Vonn, Andrew B. Nobel, and Fred A. Wright|
Tutorial for an R implementation of the DiNAMIC procedure introduced in the paper "DiNAMIC: A Method To Identify Recurrent DNA Copy Number Aberrations in Tumors" by Walter, Nobel, and Wright.
Discovering Copy Number Aberrations Manifested In Cancer (DiNAMIC), a novel method for assessing the statistical significance of recurrent copy number aberrations. In contrast to competing procedures, the testing procedure underlying DiNAMIC is carefully motivated, and employs a novel cyclic permutation scheme. Extensive simulation studies show that DiNAMIC controls false positive discoveries in a variety of realistic scenarios.
|Original Publication||DiNAMIC: Discovering copy number aberrations manifested in cancer (R).|