DiNAMIC: Discovering copy number aberrations manifested in cancer (R).

TitleDiNAMIC: Discovering copy number aberrations manifested in cancer (R).
Publication TypeSoftware
Year of Publication2011
AuthorsWalter, Vonn, Andrew B. Nobel, and Fred A. Wright
Abstract

Tutorial for an R implementation of the DiNAMIC procedure introduced in the paper "DiNAMIC: A Method To Identify Recurrent DNA Copy Number Aberrations in Tumors" by Walter, Nobel, and Wright.

Discovering Copy Number Aberrations Manifested In Cancer (DiNAMIC), a novel method for assessing the statistical significance of recurrent copy number aberrations. In contrast to competing procedures, the testing procedure underlying DiNAMIC is carefully motivated, and employs a novel cyclic permutation scheme. Extensive simulation studies show that DiNAMIC controls false positive discoveries in a variety of realistic scenarios.

Original PublicationDiNAMIC: Discovering copy number aberrations manifested in cancer (R).
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