|Title||SCORE-SeqTDS: Score tests for sequencing studies with trait-dependent sampling (C).|
|Year of Publication||2013|
|Authors||Lin, Dan-Yu, Donglin Zeng, and Zheng-Zheng Tang|
SCORE-SeqTDS is a command-line program written in the C language to implement the methods described in Lin et al. (2013) for analyzing primary and secondary quantitative traits under trait-dependent sampling. The primary trait is the trait that is used to select subjects for sequencing, and all other traits are treated as secondary. Each quantitative trait is related to a genetic variable and possibly covariates through a linear regression model. Both the maximum likelihood estimation (MLE) and standard least-squares (LS) methods are available. The MLE method properly accounts for trait-dependent sampling whereas the LS method does not. The LS method is the ideal choice for random sampling and is approximately correct for analyzing secondary quantitative traits in case-control or case-only studies with rare diseases. SCORE-SeqTDS performs the LS analysis on secondary quantitative traits for random sampling, case-control and case-only sampling. For random sampling, all traits are treated as secondary (because the sampling does not depend on any particular trait.) The sampling scheme is specified through the option -sampling. A table in the OPTIONS section below summarizes the available analysis options for different sampling schemes.
|Original Publication||SCORE-SeqTDS: Score tests for sequencing studies with trait-dependent sampling (C).|
SCORE-SeqTDS: Score tests for sequencing studies with trait-dependent sampling (C).