 Kouros Owzar, PhD
Principal Investigator, Core A Co-Director, Core B Co-Director, Project 3 Co-Leader Professor of Biostatistics and Bioinformatics Duke University School of Medicine 2424 Erwin Road Suite 1102 Dr. Owzar is Professor of Biostatistics and Bioinformatics at Duke University School of Medicine, Director of Bioinformatics at the Duke Cancer Institute, and Director of Biostatistics for the Radiation Countermeasures Center of Research Excellence at Duke. His research is focused on the development of statistical methods and computational tools for investigating the role of heritability on cancer drug induced adverse events. Dr. Owzar is a member of the Duke Cancer Institute Executive Committee, lead statistician of the Alliance Pharmacogenomics and Population Pharmacology committee, and a co-investigator of the Global Alliance for Pharmacogenomics, a joint research program between the National Institutes of Health and the Center for Genomic Medicine in Japan at the RIKEN Institute. |
| Bahmani A, Sibley A, Parsian M, Owzar K, Mueller F, 2016 IEEE International Parallel and Distributed Processing Symposium Workshops (IPDPSW)., (2016) |
| Predictive accuracy of markers or risk scores for interval censored survival data., Wu Y, Wang X, Lin J, Jia B, Owzar K, Stat Med, Volume 39, 2020 Aug 15, Issue 18, p.2437-2446. (2020) PubMed |
| Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy., Wisdom AJ, Mowery YM, Hong CS, Himes JE, Nabet BY, Qin X, Zhang D, Chen L, Fradin H, Patel R, Bassil AM, Muise ES, King DA, Xu ES, Carpenter DJ, Kent CL, Smythe KS, Williams NT, Luo L, Ma Y, Alizadeh AA, Owzar K, Diehn M, Bradley T, Kirsch DG, Nat Commun, Volume 11, 2020 Dec 17, Issue 1, p.6410. (2020) PubMed |
| The long noncoding RNA promotes sarcoma metastasis by regulating RNA splicing pathways., Huang J, Sachdeva M, Xu E, Robinson TJ, Luo L, Ma Y, Williams NT, Lopez O, Cervia LD, Yuan F, Qin X, Zhang D, Owzar K, Gokgoz N, Seto A, Okada T, Singer S, Andrulis IL, Wunder JS, Lazar AJ, Rubin BP, Pipho K, Mello SS, Giudice J, Kirsch DG, Mol Cancer Res, Volume 18, 2020 Oct, Issue 10, p.1534-1544. (2020) PubMed |
| Predictive blood-based biomarkers in patients with epithelial ovarian cancer treated with carboplatin and paclitaxel with or without bevacizumab: Results from GOG-0218., Secord AAlvarez, Burdett KBell, Owzar K, Tritchler D, Sibley AB, Liu Y, Starr MD, Brady C, Lankes HA, Hurwitz HI, Mannel RS, Tewari KS, O'Malley DM, Gray H, Bakkum-Gamez JN, Fujiwara K, Boente M, Deng W, Burger RA, Birrer MJ, Nixon AB, Clin Cancer Res, Volume 26, 2020 Mar 15, Issue 6, p.1288-1296. (2020) PubMed |
| Genomewide meta-analysis validates a role for S1PR1 in microtubule targeting agent-induced sensory peripheral neuropathy., Chua KC, Xiong C, Ho C, Mushiroda T, Jiang C, Mulkey F, Lai D, Schneider BP, Rashkin SR, Witte JS, Friedman PN, Ratain MJ, McLeod HL, Rugo HS, Shulman LN, Kubo M, Owzar K, Kroetz DL, Clin Pharmacol Ther, Volume 108, 2020 Sep, Issue 3, p.625-634. (2020) PubMed |
| fastJT: An R package for robust and efficient feature selection for machine learning and genome-wide association studies., Lin J, Sibley A, Shterev I, Nixon A, Innocenti F, Chan C, Owzar K, BMC Bioinformatics, Volume 20, 2019 Jun 13, Issue 1, p.333. (2019) PubMed |
| Efficient estimation of grouped survival models., Li Z, Lin J, Sibley AB, Truong T, Chua KC, Jiang Y, McCarthy J, Kroetz DL, Allen A, Owzar K, BMC Bioinformatics, Volume 20, 2019 May 28, Issue 1, p.269. (2019) PubMed |
| Sample size calculation for studies with grouped survival data., Li Z, Wang X, Wu Y, Owzar K, Stat Med, Volume 37, 2018 Nov 30, Issue 27, p.3904-3917. (2018) PubMed |
| Genetic variation determines VEGF-A plasma levels in cancer patients., Innocenti F, Jiang C, Sibley AB, Etheridge AS, Hatch AJ, Denning S, Niedzwiecki D, Shterev ID, Lin J, Furukawa Y, Kubo M, Kindler HL, Auman T, Venook AP, Hurwitz HI, McLeod HL, Ratain MJ, Gordân R, Nixon AB, Owzar K, Sci Rep, Volume 8, 2018 Nov 05, Issue 1, p.16332. (2018) PubMed |
| Facilitating the calculation of the efficient score using symbolic computing., Sibley A, Li Z, Jiang Y, Li YJ, Chan C, Allen A, Owzar K, Am Stat, Volume 72, 2018, Issue 2, p.199-205. (2018) PubMed |
| bcSeq: an R package for fast sequence mapping in high-throughput shRNA and CRISPR screens., Lin J, Gresham J, Wang T, Kim SYoung, Alvarez J, Damrauer JS, Floyd S, Granek J, Allen A, Chan C, Xie J, Owzar K, Bioinformatics, Volume 34, 2018 Oct 15, Issue 20, p.3581-3583. (2018) PubMed |
| Mapping eQTL by leveraging multiple tissues and DNA methylation., Acharya CR, Owzar K, Allen AS, BMC Bioinformatics, Volume 18, 2017 Oct 18, Issue 1, p.455. (2017) PubMed |
| Fitting Cox models with doubly censored data using spline-based sieve marginal likelihood., Li Z, Owzar K, Scand Stat Theory Appl, Volume 43, 2016 Jun, Issue 2, p.476-486. (2016) PubMed |
| Exploiting expression patterns across multiple tissues to map expression quantitative trait loci., Acharya CR, McCarthy JM, Owzar K, Allen AS, BMC Bioinformatics, Volume 17, 2016 Jun 24, p.257. (2016) PubMed |
| Incorporating functional information in tests of excess De Novo mutational load., Jiang Y, Han Y, Petrovski S, Owzar K, Goldstein DB, Allen AS, Am J Hum Genet, Volume 97, 2015 Aug 06, Issue 2, p.272-83. (2015) PubMed |
| A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101., Baldwin M, Owzar K, Zembutsu H, Chhibber A, Kubo M, Jiang C, Watson D, Eclov RJ, Mefford J, McLeod HL, Friedman PN, Hudis CA, Winer EP, Jorgenson EM, Witte JS, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL, Clin Cancer Res, Volume 18, 2012 Sep 15, Issue 18, p.5099-109. (2012) PubMed |
| Power and sample size calculations for SNP association studies with censored time-to-event outcomes., Owzar K, Li Z, Cox N, Jung SH, Genet Epidemiol, Volume 36, 2012 Sep, Issue 6, p.538-48. (2012) PubMed |
| SNPpy--database management for SNP data from genome wide association studies., Mitha F, Herodotou H, Borisov N, Jiang C, Yoder J, Owzar K, PLoS One, Volume 6, 2011, Issue 10, p.e24982. (2011) PubMed |
| Multiple testing for gene sets from microarray experiments., Sohn I, Owzar K, Lim J, George SL, Cushman SMackey, Jung SH, BMC Bioinformatics, Volume 12, 2011 May 26, p.209. (2011) PubMed |
| Statistical considerations for analysis of microarray experiments., Owzar K, Barry WT, Jung SH, Clin Transl Sci, Volume 4, 2011 Dec, Issue 6, p.466-77. (2011) PubMed |
| permGPU: Using graphics processing units in RNA microarray association studies., Shterev ID, Jung SH, George SL, Owzar K, BMC Bioinformatics, Volume 11, 2010 Jun 16, p.329. (2010) PubMed |
| Robust test method for time-course microarray experiments., Sohn I, Owzar K, George SL, Kim S, Jung SH, BMC Bioinformatics, Volume 11, 2010 Jul 22, p.391. (2010) PubMed |
| Owzar K, (2012) |