Title | Sample size estimation in educational intervention trials with subgroup heterogeneity in only one arm. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Esserman, Denise, Yingqi Zhao, Yiyun Tang, and Jianwen Cai |
Journal | Stat Med |
Volume | 32 |
Issue | 12 |
Pagination | 2140-54 |
Date Published | 2013 May 30 |
ISSN | 1097-0258 |
Keywords | Computer Simulation, Hepacivirus, Hepatitis C, Humans, Longitudinal Studies, Randomized Controlled Trials as Topic, Research Design, Sample Size |
Abstract | We present closed form sample size and power formulas motivated by the study of a psycho-social intervention in which the experimental group has the intervention delivered in teaching subgroups whereas the control group receives usual care. This situation is different from the usual clustered randomized trial because subgroup heterogeneity only exists in one arm. We take this modification into consideration and present formulas for the situation in which we compare a continuous outcome at both a single point in time and longitudinally over time. In addition, we present the optimal combination of parameters such as the number of subgroups and number of time points for minimizing sample size and maximizing power subject to constraints such as the maximum number of measurements that can be taken (i.e., a proxy for cost). |
DOI | 10.1002/sim.5678 |
Alternate Journal | Stat Med |
Original Publication | Sample size estimation in educational intervention trials with subgroup heterogeneity in only one arm. |
PubMed ID | 23172724 |
PubMed Central ID | PMC3615113 |
Grant List | R01 HL057444 / HL / NHLBI NIH HHS / United States P01CA142538 / CA / NCI NIH HHS / United States UL1RR025747 / RR / NCRR NIH HHS / United States UL1 RR025747 / RR / NCRR NIH HHS / United States R01HL57444 / HL / NHLBI NIH HHS / United States P01 CA142538 / CA / NCI NIH HHS / United States |
Sample size estimation in educational intervention trials with subgroup heterogeneity in only one arm.
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