Estimating Optimal Treatment Regimes from a Classification Perspective.

TitleEstimating Optimal Treatment Regimes from a Classification Perspective.
Publication TypeJournal Article
Year of Publication2012
AuthorsZhang, Baqun, Anastasios A. Tsiatis, Marie Davidian, Min Zhang, and Eric Laber
Date Published2012 Jan 01

A treatment regime maps observed patient characteristics to a recommended treatment. Recent technological advances have increased the quality, accessibility, and volume of patient-level data; consequently, there is a growing need for powerful and flexible estimators of an optimal treatment regime that can be used with either observational or randomized clinical trial data. We propose a novel and general framework that transforms the problem of estimating an optimal treatment regime into a classification problem wherein the optimal classifier corresponds to the optimal treatment regime. We show that commonly employed parametric and semi-parametric regression estimators, as well as recently proposed robust estimators of an optimal treatment regime can be represented as special cases within our framework. Furthermore, our approach allows any classification procedure that can accommodate case weights to be used without modification to estimate an optimal treatment regime. This introduces a wealth of new and powerful learning algorithms for use in estimating treatment regimes. We illustrate our approach using data from a breast cancer clinical trial.

Alternate JournalStat
Original PublicationEstimating optimal treatment regimes from a classification perspective.
PubMed ID23645940
PubMed Central IDPMC3640350
Grant ListP01 CA142538 / CA / NCI NIH HHS / United States
R01 CA085848 / CA / NCI NIH HHS / United States
R37 AI031789 / AI / NIAID NIH HHS / United States