|Title||A nonparametric spatial model for periodontal data with non-random missingness.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Reich, Brian J., Dipankar Bandyopadhyay, and Howard D. Bondell|
|Journal||J Am Stat Assoc|
|Date Published||2013 09 01|
Periodontal disease progression is often quantified by clinical attachment level (CAL) defined as the distance down a tooth's root that is detached from the surrounding bone. Measured at 6 locations per tooth throughout the mouth (excluding the molars), it gives rise to a dependent data set-up. These data are often reduced to a one-number summary, such as the whole mouth average or the number of observations greater than a threshold, to be used as the response in a regression to identify important covariates related to the current state of a subject's periodontal health. Rather than a simple one-number summary, we set forward to analyze all available CAL data for each subject, exploiting the presence of spatial dependence, non-stationarity, and non-normality. Also, many subjects have a considerable proportion of missing teeth which cannot be considered missing at random because periodontal disease is the leading cause of adult tooth loss. Under a Bayesian paradigm, we propose a nonparametric flexible spatial (joint) model of observed CAL and the location of missing tooth via kernel convolution methods, incorporating the aforementioned features of CAL data under a unified framework. Application of this methodology to a data set recording the periodontal health of an African-American population, as well as simulation studies reveal the gain in model fit and inference, and provides a new perspective into unraveling covariate-response relationships in presence of complexities posed by these data.
|Alternate Journal||J Am Stat Assoc|
|Original Publication||A nonparametric spatial model for periodontal data with non-random missingness.|
|PubMed Central ID||PMC3839869|
|Grant List||R01 MH084022 / MH / NIMH NIH HHS / United States |
R01 ES014843 / ES / NIEHS NIH HHS / United States
R03 DE020114 / DE / NIDCR NIH HHS / United States
R03 DE021762 / DE / NIDCR NIH HHS / United States
P01 CA142538 / CA / NCI NIH HHS / United States
A nonparametric spatial model for periodontal data with non-random missingness.