|Title||Weighted Area Under the Receiver Operating Characteristic Curve and Its Application to Gene Selection.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Li, Jialiang, and Jason P. Fine|
|Journal||J R Stat Soc Ser C Appl Stat|
|Date Published||2010 Aug|
Partial area under the ROC curve (PAUC) has been proposed for gene selection in Pepe et al. (2003) and thereafter applied in real data analysis. It was noticed from empirical studies that this measure has several key weaknesses, such as an inability to reflect nonuniform weighting of different decision thresholds, resulting in large numbers of ties. We propose the weighted area under the ROC curve (WAUC) in this paper to address the problems associated with PAUC. Our proposed measure enjoys a greater flexibility to describe the discrimination accuracy of genes. Nonparametric and parametric estimation methods are introduced, including PAUC as a special case, along with theoretical properties of the estimators. We also provide a simple variance formula, yielding a novel variance estimator for nonparametric estimation of PAUC, which has proven challenging in previous work. The proposed methods permit sensitivity analyses, whereby the impact of differing weight functions on gene rankings may be assessed and results may be synthesized across weights. Simulations and re-analysis of two well-known microarray datasets illustrate the practical utility of WAUC.
|Alternate Journal||J R Stat Soc Ser C Appl Stat|
|Original Publication||Weighted area under the receiver operating characteristic curve and Its application to gene selection.|
|PubMed Central ID||PMC4129959|
|Grant List||P01 CA142538 / CA / NCI NIH HHS / United States |
P30 AI050410 / AI / NIAID NIH HHS / United States
R01 CA094893 / CA / NCI NIH HHS / United States
Weighted Area Under the Receiver Operating Characteristic Curve and Its Application to Gene Selection.