Title | Semiparametric estimation of treatment effect with time-lagged response in the presence of informative censoring. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Lu, Xiaomin, and Anastasios A. Tsiatis |
Journal | Lifetime Data Anal |
Volume | 17 |
Issue | 4 |
Pagination | 566-93 |
Date Published | 2011 Oct |
ISSN | 1572-9249 |
Keywords | Anti-HIV Agents, CD4 Lymphocyte Count, Data Interpretation, Statistical, HIV, HIV Infections, Humans, Models, Statistical, Randomized Controlled Trials as Topic, Treatment Outcome |
Abstract | In many randomized clinical trials, the primary response variable, for example, the survival time, is not observed directly after the patients enroll in the study but rather observed after some period of time (lag time). It is often the case that such a response variable is missing for some patients due to censoring that occurs when the study ends before the patient's response is observed or when the patients drop out of the study. It is often assumed that censoring occurs at random which is referred to as noninformative censoring; however, in many cases such an assumption may not be reasonable. If the missing data are not analyzed properly, the estimator or test for the treatment effect may be biased. In this paper, we use semiparametric theory to derive a class of consistent and asymptotically normal estimators for the treatment effect parameter which are applicable when the response variable is right censored. The baseline auxiliary covariates and post-treatment auxiliary covariates, which may be time-dependent, are also considered in our semiparametric model. These auxiliary covariates are used to derive estimators that both account for informative censoring and are more efficient then the estimators which do not consider the auxiliary covariates. |
DOI | 10.1007/s10985-011-9199-8 |
Alternate Journal | Lifetime Data Anal |
Original Publication | Semiparametric estimation of treatment effect with time-lagged response in the presence of informative censoring. |
PubMed ID | 21706378 |
PubMed Central ID | PMC3217309 |
Grant List | P01 CA142538-01 / CA / NCI NIH HHS / United States P01 CA142538-02 / CA / NCI NIH HHS / United States R01 CA051962 / CA / NCI NIH HHS / United States R37 AI031789-22 / AI / NIAID NIH HHS / United States R01 CA051962-20 / CA / NCI NIH HHS / United States R37 AI031789 / AI / NIAID NIH HHS / United States R01 CA051962-19 / CA / NCI NIH HHS / United States P01 CA142538 / CA / NCI NIH HHS / United States R37 AI031789-21 / AI / NIAID NIH HHS / United States |
Semiparametric estimation of treatment effect with time-lagged response in the presence of informative censoring.
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