Title | Embracing rejection: Immunologic trends in brain metastasis. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | S Farber, Harrison, Vadim Tsvankin, Jessica L. Narloch, Grace J. Kim, April K. S. Salama, Gordana Vlahovic, Kimberly L. Blackwell, John P. Kirkpatrick, and Peter E. Fecci |
Journal | Oncoimmunology |
Volume | 5 |
Issue | 7 |
Pagination | e1172153 |
Date Published | 2016 Jul |
ISSN | 2162-4011 |
Abstract | Brain metastases represent the most common type of brain tumor. These tumors offer a dismal prognosis and significantly impact quality of life for patients. Their capacity for central nervous system (CNS) invasion is dependent upon induced disruptions to the blood-brain barrier (BBB), alterations to the brain microenvironment, and mechanisms for escaping CNS immunosurveillance. In the emerging era of immunotherapy, understanding how metastases are influenced by the immunologic peculiarities of the CNS will be crucial to forging therapeutic advances. In this review, the immunology of brain metastasis is explored. |
DOI | 10.1080/2162402X.2016.1172153 |
Alternate Journal | Oncoimmunology |
Original Publication | Embracing rejection: Immunologic trends in brain metastasis. |
PubMed ID | 27622023 |
PubMed Central ID | PMC5006920 |
Grant List | P01 CA142538 / CA / NCI NIH HHS / United States |
Project: