|Title||Bayesian meta-experimental design: evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Ibrahim, Joseph G., Ming-Hui Chen, Amy H Xia, and Thomas Liu|
|Date Published||2012 Jun|
|Keywords||Algorithms, Bayes Theorem, Biometry, Cardiovascular Diseases, Clinical Trials, Phase II as Topic, Clinical Trials, Phase III as Topic, Computer Simulation, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Markov Chains, Meta-Analysis as Topic, Monte Carlo Method, Randomized Controlled Trials as Topic, Risk Factors, Sample Size, Survival Analysis|
Recent guidance from the Food and Drug Administration for the evaluation of new therapies in the treatment of type 2 diabetes (T2DM) calls for a program-wide meta-analysis of cardiovascular (CV) outcomes. In this context, we develop a new Bayesian meta-analysis approach using survival regression models to assess whether the size of a clinical development program is adequate to evaluate a particular safety endpoint. We propose a Bayesian sample size determination methodology for meta-analysis clinical trial design with a focus on controlling the type I error and power. We also propose the partial borrowing power prior to incorporate the historical survival meta data into the statistical design. Various properties of the proposed methodology are examined and an efficient Markov chain Monte Carlo sampling algorithm is developed to sample from the posterior distributions. In addition, we develop a simulation-based algorithm for computing various quantities, such as the power and the type I error in the Bayesian meta-analysis trial design. The proposed methodology is applied to the design of a phase 2/3 development program including a noninferiority clinical trial for CV risk assessment in T2DM studies.
|Original Publication||Bayesian meta-experimental design: evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes.|
|PubMed Central ID||PMC3571108|
|Grant List||P30 ES010126 / ES / NIEHS NIH HHS / United States |
CA 74015 / CA / NCI NIH HHS / United States
R01 GM070335 / GM / NIGMS NIH HHS / United States
GM 70335 / GM / NIGMS NIH HHS / United States
P01 CA142538 / CA / NCI NIH HHS / United States
R01 CA074015 / CA / NCI NIH HHS / United States
Bayesian meta-experimental design: evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes.