Title | Marginal additive hazards model for case-cohort studies with multiple disease outcomes: an application to the Atherosclerosis Risk in Communities (ARIC) study. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Kang, Sangwook, Jianwen Cai, and Lloyd Chambless |
Journal | Biostatistics |
Volume | 14 |
Issue | 1 |
Pagination | 28-41 |
Date Published | 2013 Jan |
ISSN | 1468-4357 |
Keywords | Atherosclerosis, C-Reactive Protein, Case-Control Studies, Cohort Studies, Computer Simulation, Coronary Artery Disease, Coronary Disease, Humans, Proportional Hazards Models, Risk |
Abstract | In the case-cohort studies conducted within the Atherosclerosis Risk in Communities (ARIC) study, it is of interest to assess and compare the effect of high-sensitivity C-reactive protein (hs-CRP) on the increased risks of incident coronary heart disease and incident ischemic stroke. Empirical cumulative hazards functions for different levels of hs-CRP reveal an additive structure for the risks for each disease outcome. Additionally, we are interested in estimating the difference in the risk for the different hs-CRP groups. Motivated by this, we consider fitting marginal additive hazards regression models for case-cohort studies with multiple disease outcomes. We consider a weighted estimating equations approach for the estimation of model parameters. The asymptotic properties of the proposed estimators are derived and their finite-sample properties are assessed via simulation studies. The proposed method is applied to analyze the ARIC Study. |
DOI | 10.1093/biostatistics/kxs025 |
Alternate Journal | Biostatistics |
Original Publication | Marginal additive hazards model for case-cohort studies with multiple disease outcomes: an application to the Atherosclerosis Risk in Communities (ARIC) study. |
PubMed ID | 22826550 |
PubMed Central ID | PMC3520500 |
Grant List | N01-HC-55022 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States R01 HL057444 / HL / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States P01CA142538 / CA / NCI NIH HHS / United States P01 CA142538 / CA / NCI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States UL1 RR025747 / RR / NCRR NIH HHS / United States R01-HL57444 / HL / NHLBI NIH HHS / United States |
Marginal additive hazards model for case-cohort studies with multiple disease outcomes: an application to the Atherosclerosis Risk in Communities (ARIC) study.
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