Bayesian Modeling and Inference for Nonignorably Missing Longitudinal Binary Response Data with Applications to HIV Prevention Trials.

TitleBayesian Modeling and Inference for Nonignorably Missing Longitudinal Binary Response Data with Applications to HIV Prevention Trials.
Publication TypeJournal Article
Year of Publication2018
AuthorsWu, Jing, Joseph G. Ibrahim, Ming-Hui Chen, Elizabeth D. Schifano, and Jeffrey D. Fisher
JournalStat Sin
Volume28
Pagination1929-1963
Date Published2018 Oct
ISSN1017-0405
Abstract

Missing data are frequently encountered in longitudinal clinical trials. To better monitor and understand the progress over time, one must handle the missing data appropriately and examine whether the missing data mechanism is ignorable or nonignorable. In this article, we develop a new probit model for longitudinal binary response data. It resolves a challenging issue for estimating the variance of the random effects, and substantially improves the convergence and mixing of the Gibbs sampling algorithm. We show that when improper uniform priors are specified for the regression coefficients of the joint multinomial model via a sequence of one-dimensional conditional distributions for the missing data indicators under nonignorable missingness, the joint posterior distribution is improper. A variation of Jeffreys prior is thus established as a remedy for the improper posterior distribution. In addition, an efficient Gibbs sampling algorithm is developed using a collapsing technique. Two model assessment criteria, the deviance information criterion (DIC) and the logarithm of the pseudomarginal likelihood (LPML), are used to guide the choices of prior specifications and to compare the models under different missing data mechanisms. We report on extensive simulations conducted to investigate the empirical performance of the proposed methods. The proposed methodology is further illustrated using data from an HIV prevention clinical trial.

DOI10.5705/ss.202016.0319
Alternate JournalStat Sin
Original PublicationBayesian modeling and inference for nonignorably missing longitudinal binary response data with applications to HIV prevention trials.
PubMed ID30595637
PubMed Central IDPMC6309964
Grant ListP01 CA142538 / CA / NCI NIH HHS / United States
R01 GM070335 / GM / NIGMS NIH HHS / United States
R01 MH077524 / MH / NIMH NIH HHS / United States
Project: