SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) supports the prospective collection and analysis of phenotypic, biomarker, genetic, genomic, and clinical data from subjects with COPD for the purpose of identifying subpopulations and intermediate outcome measures. It is funded by the National Heart, Lung, and Blood Institute and COPD Foundation and is coordinated by the Collaborative Studies Coordinating Center at The University of North Carolina at Chapel Hill.

Research participants were enrolled, phenotyped, and are followed at twelve SPIROMICS Clinical Centers (in Winston-Salem, NC; Ann Arbor, MI; San Francisco, CA; Los Angeles, CA; New York City, NY; Salt Lake City, UT; Iowa City, IA; Baltimore, MD; Denver, CO; Philadelphia, PA; Birmingham, AL; and Chicago, IL). Molecular fingerprinting and extensive subject phenotyping will be performed to identify disease subpopulations and to identify and validate surrogate markers of disease severity which will be useful as intermediate outcome measures for future clinical trials. Secondary aims are to clarify the natural history of COPD, to develop bioinformatic resources that will enable the utilization and sharing of data in studies of COPD and related diseases, and to create a collection of clinical, biomarker, radiographic, and genetic data that can be used by external investigators for other studies of COPD.