Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.

TitleAlveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.
Publication TypePublication
Year2018
AuthorsMartinez CH, Li SX, Hirzel AJ, Stolberg VR, Alexis NE, R Barr G, Bleecker ER, Carretta EE, Christenson SA, Cooper CB, Couper DJ, Doerschuk CM, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Martinez FJ, Meyers DA, O'Neal WK, Paine R, Putcha N, Rennard SI, Woodruff PG, Zeidler M, Curtis JL, Freeman CM
Corporate AuthorsSPIROMICS Investigators
JournalJ Allergy Clin Immunol
Volume141
Issue1
Pagination429-432
Date Published2018 Jan
ISSN1097-6825
Keywordsbiomarkers, Eosinophilia, Humans, Leukocyte Count, Pulmonary Alveoli, Pulmonary Disease, Chronic Obstructive, Respiratory Function Tests, Smokers, Sputum
Abstract

Active smoking in stable COPD subjects significantly increased eosinophil accumulation in the distal airspaces, but not in sputum or peripheral blood. Our findings support the need to investigate this cell-type as a potential driver of COPD symptomatology and progression.

DOI10.1016/j.jaci.2017.07.039
Alternate JournalJ Allergy Clin Immunol
PubMed ID28916185
PubMed Central IDPMC5758424
Grant ListHHSN268200900019C / HL / NHLBI NIH HHS / United States
P30 ES005605 / ES / NIEHS NIH HHS / United States
K23 HL128936 / HL / NHLBI NIH HHS / United States
I01 BX001389 / BX / BLRD VA / United States
K23 HL123778 / HL / NHLBI NIH HHS / United States
K24 HL137013 / HL / NHLBI NIH HHS / United States
HHSN268200900015C / HL / NHLBI NIH HHS / United States
HHSN268200900016C / HL / NHLBI NIH HHS / United States
K23 HL123594 / HL / NHLBI NIH HHS / United States
I01 CX000911 / CX / CSRD VA / United States
U01 HL137880 / HL / NHLBI NIH HHS / United States
R01 HL122438 / HL / NHLBI NIH HHS / United States
HHSN268200900018C / HL / NHLBI NIH HHS / United States
P30 DK054759 / DK / NIDDK NIH HHS / United States
I01 CX001553 / CX / CSRD VA / United States
HHSN268200900017C / HL / NHLBI NIH HHS / United States
HHSN268200900020C / HL / NHLBI NIH HHS / United States
HHSN268200900013C / HL / NHLBI NIH HHS / United States
HHSN268200900014C / HL / NHLBI NIH HHS / United States
K24 HL138188 / HL / NHLBI NIH HHS / United States
P30 ES009089 / ES / NIEHS NIH HHS / United States
MS#: 
MS080
Manuscript Full Title: 
Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.
Manuscript Lead/Corresponding Author Affiliation: 
Clinical Center: Michigan (University of Michigan)
ECI: 
Manuscript Status: 
Published and Public