Research Mgr. Lisa Reeves receives the UNC BIOS Award for Staff Excellence
Dr. Shrikant Bangdiwala retires from the CSCC after 36 years!
CSCC awarded a 6th visit to its landmark ARIC study

The mission of the CSCC is to improve public health by coordinating important health research, developing innovative research methodology, and providing practical training in the application of research methods.

As the coordinating center for multi-site public health and medical studies, we provide statistical, data management, study management, and quality assurance services.

  • The CSCC’s ARIC study has been awarded a 5-year extension by the NHLBI. This will provide for a 6th visit of the ARIC cohort, which is now between their mid-70s and mid-90s in age. It is an unprecedented opportunity to evaluate risk factors for conditions related to aging, such as neurocognitive decline. Read more in the press release.

  • The CSCC has been awarded the role of Data Coordinating Center for the Medical Optimization and Management of Pregnancies with Overt Type 2 Diabetes (MOMPOD). This clinical trial, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, will examine the impact of combined Metformin and insulin therapy on infant outcomes with mothers experiencing Type 2 diabetes in pregnancy. CSCC Director Sonia David, DrPH, is the co-PI, joined by three colleagues from the UNC School of Medicine and School of Nursing. Read more in the BIOS press release.

  • The October issue of Circulation: Heart Failure has published a paper directly from the results of the Women’s Health Initiative (WHI). “Risk Factors for Incident Hospitalized Heart Failure With Preserved Versus Reduced Ejection Fraction in a Multiracial Cohort of Postmenopausal Women” is co-authored by WHI co-Investigator Dr. Wayne Rosamond, a CSCC Investigator and Professor of Epidemiology at UNC.

  • Dr. Matthew Loop joins the CSCC!

    Matthew, a graduate of the University of Alabama at Birmingham in 2015, joins us as a Clinical Assistant Professor. His dissertation focused on methods of analyzing geographic disparities in hypertension using a large cohort study. He then went on to complete a postdoctoral fellowship at UAB in Epidemiology as part of the Vascular Biology and Hypertension Training Program.

  • The Collaborative Studies Coordinating Center has been awarded funding by the NIH to serve as the coordinating center for the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN), a research network devoted to the health and well-being of adolescents and young adults with HIV or at risk for HIV infection. CSCC investigator Dr. Myra Carpenter is co-PI with the UNC Department of Biostatistics' Dr. Michael Hudgens.

  • Dr. Matt Psioda joins the ranks of the CSCC!

    Matt, a recent graduate of UNC in 2016, joins us as a Research Assistant Professor. His dissertation focused on statistical methods for Bayesian clinical trial design and statistical methods for epigenetic studies.

  • Dr. David Couper, the CSCC's PI on the SPIROMICS study, recently co-authored a high-impact paper relating COPD-like symptoms to smoking history. "Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function" is in the May issue of the New England Journal of Medicine. Read more here.

  • In May, the CSCC Atherosclerosis Risk in Communities (ARIC) team hosted its field center staff for a centralized training at various locations in UNC's Gillings School of Global Public Health space. Neurological and clinical testing, physical function, biospecimen collection and processing, and proper results reporting were among the sessions offered during the 3 day event. The new Visit 6 of ARIC extends the study (now in its 31st year) in a new direction focused on neurocognitive impairments.

    Thanks to all the trainers, trainees, and staff for making this event a success!

  • In April, the CSCC and Department of Biostatistics celebrated a few outstanding staff members at a ceremony at our center. Our 2016 Star Heels are Barbara Brown, Sheila Burgard, and Kim Ring. The Staff Award for Excellence went to Kwanhye Jung (a 2016 MPH graduate, to boot). Congratulations to them, and many thanks to all of the Coordinating Center staff!

  • CSCC Investigators Daniela Sotres-Alvarez and Gerardo Heiss, along with former GRA Andy Ni, are supporting authors on a recently published article in a special issue of Circulation. 'Parity and components of the metabolic syndrome among U.S. Hispanic/Latina women: Results from the HCHS/SOL Study' examines the relation between the number of births a Hispanic/Latina woman has to the likelihood of developing certain kinds of risk factors for heart disease. Read more here.

  • The CSCC's Dental Toolkit is highlighted in the UNC Department of Biostatistics' 2015 publication, BiosRhythms.

  • Our SPIROMICS study finished its enrolment period at the end of July this year, gathering 2,981 patients! SPIROMICS is a prospective cohort study that enrolled participants with COPD at twelve clinical centers over five years. Its primary goal is to identify subpopulations and intermediate outcome measures in COPD through molecular fingerprinting and extensive subject phenotyping. (Study Design paper in Thorax)

  • The CSCC is very proud to have so many of our staff recognized in the recent 2015 Department of Biostatistics employee appreciation ceremony! Hengrui Sun, Summer Sun, and Pingping Wu were all deemed Carolina StarHeels. Betsy Carretta was awarded the Annual Staff Award for Excellence.

  • In April, the Predicting Response to Standardized Pediatric Colitis Therapy (PROTECT) study completed enrollment with a total of 467 participants. Enrollment ended three months early with almost 40 more participants that originally planned. (Enrollment graph) PROTECT is a multi-center prospective cohort study of standardized medical therapy (mesalamine or corticosteroids) in newly diagnosed ulcerative colitis in children and adolescents. Sonia Davis is the CSCC PI.

  • Our Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) study has been named one of the Top 10 Clinical Research Achievements for 2015 by the Clinical Research Forum. RIVUR Trial Investigator Dr. Alejandro Hoberman recorded a short video summing up recent discoveries. The CSCC PI is Myra Carpenter.

  • Dr. Gerardo Heiss, Kenan Distinguished Professor of Epidemiology and CSCC Principal Investigator, has been awarded the American Heart Association's 2015 Epidemiology and Prevention Mentoring Award.

  • In January, CSCC Investigator Lisa Wruck was promoted to Research Associate Professor in the UNC Dept of Biostatistics. Dr. Wruck is co-PI of the Atherosclerosis Risk in Communities (ARIC) Coordinating Center and PI of the ARIC Neurocognitive Study (NCS) Coordinating Center.

  • The CSCC’s new LIBERTI (Laser Induced, Biologically Engineered Remodeling of Thermally Injured) Skin Trial is finalizing the protocol and is expected to randomize its first participants soon. This Sequential Multiple Assignment Randomized Trial (SMART) was developed by UNC Biostatistics Chair Michael Kosorok to investigate the best way to use laser treatment to improve severe burn scars.

  • Just ahead of its 30th birthday in 2015, the ARIC study celebrated reaching the 1000 publications mark this summer. Between January and October 2014, alone, ARIC has produced 128 articles.
  • This fall, the SPIROMICS Exacerbation Substudy began enrolling a subset of SPIROMICS participants who will complete daily symptom diaries using smart phone-type devices.

  • Dr. Jim Beck, executive associate dean of the UNC School of Dentistry, has authored two articles in the June and August editions of the Journal of American Dentistry Association based on findings from the HCHS/SOL study.
  • Dr. Jianwen Cai has been elected the 2016 president of the International Biometric Society’s (IBS) Eastern North American Region (ENAR). She will also hold the positions of president-elect and past-president for 2015 and 2017, respectively. Dr. Cai is the CSCC PI to the HCHS/SOL study.

  • Senior Biostatistician Yanping Teng is a major contributor to two HCHS/SOL papers in the August issue of Diabetes Care. They examine the prevalence of metabolic syndrome and diabetes among the US Hispanic and Latino population. Other UNC authors include Gerardo Heiss, Laura Loehr, and Michelle Snyder.
  • Natalia Gouskova, CSCC senior biostatistician and doctoral candidate in biostatistics at UNC, received a "Best Poster” award at the 2014 Statistical Analysis of Multi-Outcome Data workshop. It was based on her paper, “Viral Suppression in HIV Studies: Combining Times to Suppression and Rebound”, published in Biometrics earlier this year.

  • We congratulate Lisa Gravens-Mueller for being selected as the 2014 winner of the James D. Hosking Memorial Award. This award is granted every year to a deserving member of the CSCC staff and faculty, to be used for education or training geared towards professional development.

  • The ACLAIMS study recently published its primary manuscript in the May 21 issue of the Journal of the American Medical Association. CSCC statisticians Rosalie Dominik, Neepa Ray, and Tania Wilkins were co-authors on the manuscript. (SPH summary)

  • Marston Youngblood is second author to Dr. Jim Beck's (executive associate dean of the UNC School of Dentistry) cover article in June's issue of JADA, which is the first to analyze dental conditions in the US Hispanic and Latino population as part of the HCHS/SOL study.

  • We mourn the passing of Joy Cook, who succumbed to a cystic fibrosis related illness on May 18th, 2014. Joy was a strong and bright person, and a model researcher at the CSCC. A lifelong Tarheel, her senior year at UNC was put on hold by major CF complications and a lung transplant surgery in December 2006 at UNC Hospitals. Afterwards, while recovering, she strove with great commitment to earn a double major in Public Policy and Communications in 2007. She began working at the CSCC shortly after, contributing to both of our lung related projects, SPIROMICS and the Bronchiectasis Research Registry. In her spare time, Joy was active in her church and various CF charities, such as the Sweet Melissa Fund and the yearly Great Strides walks. We will miss her greatly, and extend our deepest sympathies to her family and friends.

  • The CSCC is proud to see four of our student assistants graduate this May with Bachelor of Science in Public Health degrees from the Gillings School of Global Public Health at UNC! We will miss them, but know that their futures are bright.

  • CSCC Director Sonia Davis has co-published a chapter, "Mixed models for repeated measures using categorical time effects", in Wiley's Clinical Trials with Missing Data: A Guide for Practitioners.

  • Drs. Anastasia Ivanova and Sonia Davis gave separate presentations (1, 2) and lead short courses at the 2014 Trends and Innovations in Clinical Trials Statistics (TICTS) conference.

  • Our ACLAIMS Study has completed its recruitment phase in July of 2012