Title | DiNAMIC: Discovering copy number aberrations manifested in cancer (R). |
Publication Type | Software |
Year of Publication | 2011 |
Authors | Walter, Vonn, Andrew B. Nobel, and Fred A. Wright |
Abstract | Tutorial for an R implementation of the DiNAMIC procedure introduced in the paper "DiNAMIC: A Method To Identify Recurrent DNA Copy Number Aberrations in Tumors" by Walter, Nobel, and Wright. Discovering Copy Number Aberrations Manifested In Cancer (DiNAMIC), a novel method for assessing the statistical significance of recurrent copy number aberrations. In contrast to competing procedures, the testing procedure underlying DiNAMIC is carefully motivated, and employs a novel cyclic permutation scheme. Extensive simulation studies show that DiNAMIC controls false positive discoveries in a variety of realistic scenarios. |
Original Publication | DiNAMIC: Discovering copy number aberrations manifested in cancer (R). |
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