Prospects and challenges for clinical decision support in the era of big data.

TitleProspects and challenges for clinical decision support in the era of big data.
Publication TypeJournal Article
Year of Publication2018
AuthorsNaqa, Issam El, Michael R. Kosorok, Judy Jin, Michelle Mierzwa, and Randall K. Ten Haken
JournalJCO Clin Cancer Inform
Date Published2018
KeywordsBig Data, Data Mining, Data Science, Decision Support Systems, Clinical, Humans, Machine Learning, Medical Oncology, Outcome and Process Assessment, Health Care, Precision Medicine, User-Computer Interface

Recently, there has been burgeoning interest in developing more effective and robust clinical decision support systems (CDSSs) for oncology. This has been primarily driven by the demands for more personalized and precise medical practice in oncology in the era of so-called Big Data (BD); an era that promises to harness the power of large-scale data flow to revolutionize cancer treatment. This interest in BD analytics has created new opportunities as well as new unmet challenges. These include: routine aggregation and standardization of clinical data; patient privacy; transformation of current analytical approaches to handle such noisy and heterogeneous data; and expanded use of advanced statistical learning methods based on confluence of modern statistical methods and machine learning algorithms. In this review, we present the current status of CDSSs in oncology, the prospects and current challenges of BD analytics, and the promising role of integrated modern statistics and machine learning algorithms in predicting complex clinical endpoints, individualizing treatment rules, and optimizing dynamic personalized treatment regimens. We discuss issues pertaining to these topics and present application examples from an aggregate of experiences. We also discuss the role of human factors in improving the utilization and acceptance of such enhanced CDSSs and how to mitigate possible sources of human error to achieve optimal performance and wider acceptance.

Alternate JournalJCO Clin Cancer Inform
Original PublicationProspects and challenges for clinical decision support in the era of big data.
PubMed ID30613823
PubMed Central IDPMC6317743
Grant ListP01 CA059827 / CA / NCI NIH HHS / United States
P01 CA142538 / CA / NCI NIH HHS / United States