Entropy Learning for Dynamic Treatment Regimes.

TitleEntropy Learning for Dynamic Treatment Regimes.
Publication TypeJournal Article
Year of Publication2019
AuthorsJiang, Binyan, Rui Song, Jialiang Li, and Donglin Zeng
JournalStat Sin
Date Published2019

Estimating optimal individualized treatment rules (ITRs) in single or multi-stage clinical trials is one key solution to personalized medicine and has received more and more attention in statistical community. Recent development suggests that using machine learning approaches can significantly improve the estimation over model-based methods. However, proper inference for the estimated ITRs has not been well established in machine learning based approaches. In this paper, we propose a entropy learning approach to estimate the optimal individualized treatment rules (ITRs). We obtain the asymptotic distributions for the estimated rules so further provide valid inference. The proposed approach is demonstrated to perform well in finite sample through extensive simulation studies. Finally, we analyze data from a multi-stage clinical trial for depression patients. Our results offer novel findings that are otherwise not revealed with existing approaches.

Alternate JournalStat Sin
Original PublicationEntropy learning for dynamic treatment regimes.
PubMed ID31534307
PubMed Central IDPMC6750237
Grant ListP01 CA142538 / CA / NCI NIH HHS / United States
R01 GM124104 / GM / NIGMS NIH HHS / United States