Title | Longitudinal regression analysis of spatial-temporal growth patterns of geometrical diffusion measures in early postnatal brain development with diffusion tensor imaging. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Chen, Yasheng, Hongyu An, Hongtu Zhu, Valerie Jewells, Diane Armao, Dinggang Shen, John H. Gilmore, and Weili Lin |
Journal | Neuroimage |
Volume | 58 |
Issue | 4 |
Pagination | 993-1005 |
Date Published | 2011 Oct 15 |
ISSN | 1095-9572 |
Keywords | Algorithms, Anisotropy, Brain, Brain Mapping, Child, Preschool, Diffusion Tensor Imaging, Female, Humans, Image Processing, Computer-Assisted, Infant, Infant, Newborn, Linear Models, Longitudinal Studies, Male, Regression Analysis |
Abstract | Although diffusion tensor imaging (DTI) has provided substantial insights into early brain development, most DTI studies based on fractional anisotropy (FA) and mean diffusivity (MD) may not capitalize on the information derived from the three principal diffusivities (e.g. eigenvalues). In this study, we explored the spatial and temporal evolution of white matter structures during early brain development using two geometrical diffusion measures, namely, linear (Cl) and planar (Cp) diffusion anisotropies, from 71 longitudinal datasets acquired from 29 healthy, full-term pediatric subjects. The growth trajectories were estimated with generalized estimating equations (GEE) using linear fitting with logarithm of age (days). The presence of the white matter structures in Cl and Cp was observed in neonates, suggesting that both the cylindrical and fanning or crossing structures in various white matter regions may already have been formed at birth. Moreover, we found that both Cl and Cp evolved in a temporally nonlinear and spatially inhomogeneous manner. The growth velocities of Cl in central white matter were significantly higher when compared to peripheral, or more laterally located, white matter: central growth velocity Cl=0.0465±0.0273/log(days), versus peripheral growth velocity Cl=0.0198±0.0127/log(days), p<10⁻⁶. In contrast, the growth velocities of Cp in central white matter were significantly lower than that in peripheral white matter: central growth velocity Cp=0.0014±0.0058/log(days), versus peripheral growth velocity Cp=0.0289±0.0101/log(days), p<10⁻⁶. Depending on the underlying white matter site which is analyzed, our findings suggest that ongoing physiologic and microstructural changes in the developing brain may exert different effects on the temporal evolution of these two geometrical diffusion measures. Thus, future studies utilizing DTI with correlative histological analysis in the study of early brain development are warranted. |
DOI | 10.1016/j.neuroimage.2011.07.006 |
Alternate Journal | Neuroimage |
Original Publication | Longitudinal regression analysis of spatial-temporal growth patterns of geometrical diffusion measures in early postnatal brain development with diffusion tensor imaging. |
PubMed ID | 21784163 |
PubMed Central ID | PMC3299497 |
Grant List | P01CA142538-01 / CA / NCI NIH HHS / United States R01 NS055754-04 / NS / NINDS NIH HHS / United States R01 MH070890-01 / MH / NIMH NIH HHS / United States R01 MH060352-04 / MH / NIMH NIH HHS / United States R01 MH070890-04 / MH / NIMH NIH HHS / United States R01 MH070890-07 / MH / NIMH NIH HHS / United States R01 HD053000-03S1 / HD / NICHD NIH HHS / United States R01 NS037312-02 / NS / NINDS NIH HHS / United States R21 AG033387-02 / AG / NIA NIH HHS / United States R01 NS054079-04S1 / NS / NINDS NIH HHS / United States AG033387 / AG / NIA NIH HHS / United States R01EB008374 / EB / NIBIB NIH HHS / United States R01 MH060352 / MH / NIMH NIH HHS / United States R01 EB008374 / EB / NIBIB NIH HHS / United States R01 NS055754-01A1 / NS / NINDS NIH HHS / United States S10 RR025050 / RR / NCRR NIH HHS / United States P50 MH064065-04 / MH / NIMH NIH HHS / United States R01 EB006733 / EB / NIBIB NIH HHS / United States R01 MH060352-03 / MH / NIMH NIH HHS / United States R01 NS054079-05 / NS / NINDS NIH HHS / United States R01 NS054079-03 / NS / NINDS NIH HHS / United States 1R01EB006733 / EB / NIBIB NIH HHS / United States R01 HD053000-05 / HD / NICHD NIH HHS / United States R01 HD053000-04 / HD / NICHD NIH HHS / United States R01 MH070890-03 / MH / NIMH NIH HHS / United States P50 MH064065-09 / MH / NIMH NIH HHS / United States P50 MH064065-08S2 / MH / NIMH NIH HHS / United States R01 MH086633-02 / MH / NIMH NIH HHS / United States P50 MH064065-05 / MH / NIMH NIH HHS / United States R01 HD053000-01A1 / HD / NICHD NIH HHS / United States R01 MH070890-08 / MH / NIMH NIH HHS / United States R01 NS055754-05 / NS / NINDS NIH HHS / United States R01NS055754 / NS / NINDS NIH HHS / United States P50 MH064065-03 / MH / NIMH NIH HHS / United States S10 RR019924 / RR / NCRR NIH HHS / United States R01 NS037312-03 / NS / NINDS NIH HHS / United States R01 HD053000-03 / HD / NICHD NIH HHS / United States R01 MH086633-03 / MH / NIMH NIH HHS / United States S10 RR019924-01 / RR / NCRR NIH HHS / United States R01 MH060352-02 / MH / NIMH NIH HHS / United States R21 AG033387-01A1 / AG / NIA NIH HHS / United States S10 RR025050-01 / RR / NCRR NIH HHS / United States R01 MH060352-01A1 / MH / NIMH NIH HHS / United States R01 NS054079-04 / NS / NINDS NIH HHS / United States R01 MH070890-06A1 / MH / NIMH NIH HHS / United States P50 MH064065-08S1 / MH / NIMH NIH HHS / United States R01 NS037312-04 / NS / NINDS NIH HHS / United States R01 MH086633 / MH / NIMH NIH HHS / United States P50 MH064065 / MH / NIMH NIH HHS / United States R01 NS054079 / NS / NINDS NIH HHS / United States R01 MH086633-01A1 / MH / NIMH NIH HHS / United States R01 NS055754 / NS / NINDS NIH HHS / United States S10 RR017212-01 / RR / NCRR NIH HHS / United States RR025747-01 / RR / NCRR NIH HHS / United States P50 MH064065-08 / MH / NIMH NIH HHS / United States R01 MH070890-05S1 / MH / NIMH NIH HHS / United States R01MH070890 / MH / NIMH NIH HHS / United States P50 MH064065-07 / MH / NIMH NIH HHS / United States P50 MH064065-10 / MH / NIMH NIH HHS / United States R01 MH070890 / MH / NIMH NIH HHS / United States R01 EB009634 / EB / NIBIB NIH HHS / United States R01 HD053000-02 / HD / NICHD NIH HHS / United States R01 HD053000 / HD / NICHD NIH HHS / United States P50 MH064065-06 / MH / NIMH NIH HHS / United States R01HD053000 / HD / NICHD NIH HHS / United States MH086633 / MH / NIMH NIH HHS / United States UL1 RR025747 / RR / NCRR NIH HHS / United States R01 MH070890-05 / MH / NIMH NIH HHS / United States R01 MH070890-02 / MH / NIMH NIH HHS / United States R01 NS054079-01A1 / NS / NINDS NIH HHS / United States R01 NS054079-02 / NS / NINDS NIH HHS / United States 1R01EB009634 / EB / NIBIB NIH HHS / United States P01 CA142538 / CA / NCI NIH HHS / United States R01 NS037312-01A1 / NS / NINDS NIH HHS / United States R01 NS055754-03 / NS / NINDS NIH HHS / United States R21 AG033387 / AG / NIA NIH HHS / United States R01 NS055754-02 / NS / NINDS NIH HHS / United States R01 NS035147-05 / NS / NINDS NIH HHS / United States |
Longitudinal regression analysis of spatial-temporal growth patterns of geometrical diffusion measures in early postnatal brain development with diffusion tensor imaging.
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