Sex differences in grey matter atrophy patterns among AD and aMCI patients: results from ADNI.

TitleSex differences in grey matter atrophy patterns among AD and aMCI patients: results from ADNI.
Publication TypeJournal Article
Year of Publication2011
AuthorsSkup, Martha, Hongtu Zhu, Yaping Wang, Kelly S. Giovanello, Ja-an Lin, Dinggang Shen, Feng Shi, Wei Gao, Weili Lin, Yong Fan, and Heping Zhang
Corporate AuthorsAlzheimer's Disease Neuroimaging Initiative
JournalNeuroimage
Volume56
Issue3
Pagination890-906
Date Published2011 Jun 01
ISSN1095-9572
KeywordsAged, Aging, Alzheimer Disease, Atrophy, Brain, Brain Mapping, Cluster Analysis, Cognition Disorders, Disease Progression, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Positron-Emission Tomography, Sex Characteristics
Abstract

We used longitudinal magnetic resonance imaging (MRI) data to determine whether there are any gender differences in grey matter atrophy patterns over time in 197 individuals with probable Alzheimer's disease (AD) and 266 with amnestic mild cognitive impairment (aMCI), compared with 224 healthy controls participating in the Alzheimer's Disease Neuroimaging Initiative (ADNI). While previous research has differentiated probable AD and aMCI groups from controls in brain atrophy, it is unclear whether and how sex plays a role in patterns of change over time. Using regional volumetric maps, we fit longitudinal models to the grey matter data collected at repeated occasions, seeking differences in patterns of volume change over time by sex and diagnostic group in a voxel-wise analysis. Additionally, using a region-of-interest approach, we fit longitudinal models to the global volumetric data of predetermined brain regions to determine whether this more conventional approach is sufficient for determining sex and group differences in atrophy. Our longitudinal analyses revealed that, of the various grey matter regions investigated, males and females in the AD group and the aMCI group showed different patterns of decline over time compared to controls in the bilateral precuneus, bilateral caudate nucleus, right entorhinal gyrus, bilateral thalamus, bilateral middle temporal gyrus, left insula, and right amygdala. As one of the first investigation to model more than two time points of structural MRI data over time, our findings add insight into how AD and aMCI males and females differ from controls and from each other over time.

DOI10.1016/j.neuroimage.2011.02.060
Alternate JournalNeuroimage
Original PublicationSex differences in grey matter atrophy patterns among AD and aMCI patients: results from ADNI.
PubMed ID21356315
PubMed Central IDPMC3085726
Grant ListK01 AG028774-02 / AG / NIA NIH HHS / United States
T32 MH014235-32 / MH / NIMH NIH HHS / United States
T32 MH014235-36 / MH / NIMH NIH HHS / United States
R01 NS037312-03 / NS / NINDS NIH HHS / United States
R01 MH086633-03 / MH / NIMH NIH HHS / United States
P01CA142538-01 / CA / NCI NIH HHS / United States
R01EB5-34816 / EB / NIBIB NIH HHS / United States
R01 NS055754-02 / NS / NINDS NIH HHS / United States
T32 MH014235-35 / MH / NIMH NIH HHS / United States
K01 AG030514 / AG / NIA NIH HHS / United States
R01 NS037312-02 / NS / NINDS NIH HHS / United States
R21 AG033387-02 / AG / NIA NIH HHS / United States
R01 NS054079-04S1 / NS / NINDS NIH HHS / United States
R01 NS055754-01A1 / NS / NINDS NIH HHS / United States
U01 AG024904-01 / AG / NIA NIH HHS / United States
T32 MH014235 / MH / NIMH NIH HHS / United States
R01 NS054079-05 / NS / NINDS NIH HHS / United States
R01 NS054079-03 / NS / NINDS NIH HHS / United States
R01 MH086633-02 / MH / NIMH NIH HHS / United States
U01 AG024904 / AG / NIA NIH HHS / United States
R01 NS055754-05 / NS / NINDS NIH HHS / United States
R01NS055754 / NS / NINDS NIH HHS / United States
R21 AG033387-01A1 / AG / NIA NIH HHS / United States
R01 NS054079-04 / NS / NINDS NIH HHS / United States
K01 AG028774-05 / AG / NIA NIH HHS / United States
R01 NS037312-04 / NS / NINDS NIH HHS / United States
R01 MH086633 / MH / NIMH NIH HHS / United States
AG03338 / AG / NIA NIH HHS / United States
R01 NS054079 / NS / NINDS NIH HHS / United States
R01 MH086633-01A1 / MH / NIMH NIH HHS / United States
R01 NS055754 / NS / NINDS NIH HHS / United States
RR025747-01 / RR / NCRR NIH HHS / United States
R01 NS055754-04 / NS / NINDS NIH HHS / United States
T32 MH014235-37 / MH / NIMH NIH HHS / United States
T32 MH014235-34 / MH / NIMH NIH HHS / United States
K01 AG028774-04 / AG / NIA NIH HHS / United States
K01 AG028774 / AG / NIA NIH HHS / United States
MH086633 / MH / NIMH NIH HHS / United States
UL1 RR025747 / RR / NCRR NIH HHS / United States
R01 NS054079-01A1 / NS / NINDS NIH HHS / United States
P30 AG010129 / AG / NIA NIH HHS / United States
T32 MH014235-29 / MH / NIMH NIH HHS / United States
R01 NS054079-02 / NS / NINDS NIH HHS / United States
P01 CA142538 / CA / NCI NIH HHS / United States
R01 NS037312-01A1 / NS / NINDS NIH HHS / United States
R01 NS055754-03 / NS / NINDS NIH HHS / United States
T32 MH014235-33 / MH / NIMH NIH HHS / United States
R21 AG033387 / AG / NIA NIH HHS / United States
K01 AG028774-01A1 / AG / NIA NIH HHS / United States
T32 MH014235-31 / MH / NIMH NIH HHS / United States
K01 AG028774-03 / AG / NIA NIH HHS / United States
T32 MH014235-30 / MH / NIMH NIH HHS / United States
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