Estimating effect of environmental contaminants on women's subfecundity for the MoBa study data with an outcome-dependent sampling scheme.

TitleEstimating effect of environmental contaminants on women's subfecundity for the MoBa study data with an outcome-dependent sampling scheme.
Publication TypeJournal Article
Year of Publication2014
AuthorsDing, Jieli, Haibo Zhou, Yanyan Liu, Jianwen Cai, and Matthew P. Longnecker
JournalBiostatistics
Volume15
Issue4
Pagination636-50
Date Published2014 Oct
ISSN1468-4357
KeywordsAdult, Caprylates, Cohort Studies, Environmental Exposure, Environmental Pollutants, Female, Fertility, Fluorocarbons, Humans, Likelihood Functions, Norway, Pregnancy, Proportional Hazards Models
Abstract

Motivated by the need from our on-going environmental study in the Norwegian Mother and Child Cohort (MoBa) study, we consider an outcome-dependent sampling (ODS) scheme for failure-time data with censoring. Like the case-cohort design, the ODS design enriches the observed sample by selectively including certain failure subjects. We present an estimated maximum semiparametric empirical likelihood estimation (EMSELE) under the proportional hazards model framework. The asymptotic properties of the proposed estimator were derived. Simulation studies were conducted to evaluate the small-sample performance of our proposed method. Our analyses show that the proposed estimator and design is more efficient than the current default approach and other competing approaches. Applying the proposed approach with the data set from the MoBa study, we found a significant effect of an environmental contaminant on fecundability.

DOI10.1093/biostatistics/kxu016
Alternate JournalBiostatistics
Original PublicationEstimating effect of environmental contaminants on women's subfecundity for the MoBa study data with an outcome-dependent sampling scheme.
PubMed ID24812419
PubMed Central IDPMC4168316
Grant ListUL1 RR025747 / RR / NCRR NIH HHS / United States
UO1 NS 047537-01 / NS / NINDS NIH HHS / United States
UO1 NS 047537-06A1 / NS / NINDS NIH HHS / United States
/ ImNIH / Intramural NIH HHS / United States
N01-ES-75558 / ES / NIEHS NIH HHS / United States
P01 CA142538 / CA / NCI NIH HHS / United States
R01 ES021900 / ES / NIEHS NIH HHS / United States
Project: