|Predicting Alzheimer's Disease Using Combined Imaging-Whole Genome SNP Data.
|Year of Publication
|Kong, Dehan, Kelly S. Giovanello, Yalin Wang, Weili Lin, Eunjee Lee, Yong Fan, Murali P Doraiswamy, and Hongtu Zhu
|J Alzheimers Dis
|Aged, Aged, 80 and over, Alzheimer Disease, Apolipoprotein E4, Cognitive Dysfunction, Female, Genetic Association Studies, Genome, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Polymorphism, Single Nucleotide, Principal Component Analysis, Psychiatric Status Rating Scales
The growing public threat of Alzheimer's disease (AD) has raised the urgency to discover and validate prognostic biomarkers in order to predicting time to onset of AD. It is anticipated that both whole genome single nucleotide polymorphism (SNP) data and high dimensional whole brain imaging data offer predictive values to identify subjects at risk for progressing to AD. The aim of this paper is to test whether both whole genome SNP data and whole brain imaging data offer predictive values to identify subjects at risk for progressing to AD. In 343 subjects with mild cognitive impairment (MCI) enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI-1), we extracted high dimensional MR imaging (volumetric data on 93 brain regions plus a surface fluid registration based hippocampal subregion and surface data), and whole genome data (504,095 SNPs from GWAS), as well as routine neurocognitive and clinical data at baseline. MCI patients were then followed over 48 months, with 150 participants progressing to AD. Combining information from whole brain MR imaging and whole genome data was substantially superior to the standard model for predicting time to onset of AD in a 48-month national study of subjects at risk. Our findings demonstrate the promise of combined imaging-whole genome prognostic markers in people with mild memory impairment.
|J Alzheimers Dis
|Predicting Alzheimer's disease using combined imaging-whole genome SNP data.
|PubMed Central ID
|AG033387 / AG / NIA NIH HHS / United States
UL1 TR001111 / TR / NCATS NIH HHS / United States
U01 AG024904 / AG / NIA NIH HHS / United States
UL1 TR002489 / TR / NCATS NIH HHS / United States
R21 AG043760 / AG / NIA NIH HHS / United States
P01CA142538-01 / CA / NCI NIH HHS / United States
1UL1TR001111 / TR / NCATS NIH HHS / United States
R01 MH086633 / MH / NIMH NIH HHS / United States
T32 MH106440 / MH / NIMH NIH HHS / United States
MH086633 / MH / NIMH NIH HHS / United States
UL1 RR025747 / RR / NCRR NIH HHS / United States
P01 CA142538 / CA / NCI NIH HHS / United States
R21 AG033387 / AG / NIA NIH HHS / United States