Title | Performance of rapid influenza H1N1 diagnostic tests: a meta-analysis. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Chu, Haitao, Eric T. Lofgren, Elizabeth M Halloran, Pei F. Kuan, Michael Hudgens, and Stephen R. Cole |
Journal | Influenza Other Respir Viruses |
Volume | 6 |
Issue | 2 |
Pagination | 80-6 |
Date Published | 2012 Mar |
ISSN | 1750-2659 |
Keywords | Diagnostic Tests, Routine, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Sensitivity and Specificity, Virology |
Abstract | BACKGROUND: Following the outbreaks of 2009 pandemic H1N1 infection, rapid influenza diagnostic tests have been used to detect H1N1 infection. However, no meta-analysis has been undertaken to assess the diagnostic accuracy when this manuscript was drafted.METHODS: The literature was systematically searched to identify studies that reported the performance of rapid tests. Random effects meta-analyses were conducted to summarize the overall performance.RESULTS: Seventeen studies were selected with 1879 cases and 3477 non-cases. The overall sensitivity and specificity estimates of the rapid tests were 0·51 (95%CI: 0·41, 0·60) and 0·98 (95%CI: 0·94, 0·99). Studies reported heterogeneous sensitivity estimates, ranging from 0·11 to 0·88. If the prevalence was 30%, the overall positive and negative predictive values were 0·94 (95%CI: 0·85, 0·98) and 0·82 (95%CI: 0·79, 0·85). The overall specificities from different manufacturers were comparable, while there were some differences for the overall sensitivity estimates. BinaxNOW had a lower overall sensitivity of 0·39 (95%CI: 0·24, 0·57) compared with all the others (P-value <0·001), whereas QuickVue had a higher overall sensitivity of 0·57 (95%CI: 0·50, 0·63) compared with all the others (P-value = 0·005).CONCLUSIONS: Rapid tests have high specificity but low sensitivity and thus limited usefulness. |
DOI | 10.1111/j.1750-2659.2011.00284.x |
Alternate Journal | Influenza Other Respir Viruses |
Original Publication | Performance of rapid influenza H1N1 diagnostic tests: a meta-analysis. |
PubMed ID | 21883964 |
PubMed Central ID | PMC3288365 |
Grant List | R03HS020666 / HS / AHRQ HHS / United States P01 CA142538-02 / CA / NCI NIH HHS / United States P01CA142538 / CA / NCI NIH HHS / United States P01 CA142538 / CA / NCI NIH HHS / United States P01 CA142538-01 / CA / NCI NIH HHS / United States P01 CA142538-03 / CA / NCI NIH HHS / United States |
Performance of rapid influenza H1N1 diagnostic tests: a meta-analysis.
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