|Tutorial: Getting SMART about Dynamic Treatment Regimes: A Conceptual Introduction
|Year of Publication
The effective treatment and management of a wide variety of health disorders often requires individualized, sequential decision-making. To do this, each patient’s treatment is dynamically adapted over time based on the patient’s history and changing disease state.
Dynamic treatment regimes (also known as adaptive interventions) operationalize individualized decision making using a sequence of decision rules that specify whether, how, for whom, or when to alter the dose, type, or delivery of pharmacological, behavioral, and/or psychosocial treatments. Recently, there has been a surge of clinical and methodological interest in developing and evaluating dynamic treatment regimes via clinical trials. Specifically, there is great interest in the use of sequential multiple assignment randomized trials (SMART), a type of multi-stage randomized trial design, to build dynamic treatment regimes. The aims of this tutorial are
1. Dynamic Treatment Regimes (also known as Adaptive Interventions)
Tutorial: Getting SMART about Dynamic Treatment Regimes: A Conceptual Introduction