Animals
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Apoptosis
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
bcl-X Protein
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Breast Neoplasms
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Cell Line, Tumor
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Class I Phosphatidylinositol 3-Kinases
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Combinatorial Chemistry Techniques
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
DNA Mutational Analysis
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Female
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Gene Expression Regulation, Neoplastic
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Humans
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
MAP Kinase Signaling System
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Mice
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Mice, Nude
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Molecular Targeted Therapy
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Mutation
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Myeloid Cell Leukemia Sequence 1 Protein
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Neoplasm Transplantation
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
Proto-Oncogene Proteins c-bcl-2
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.
TOR Serine-Threonine Kinases
Anderson, Gray R., Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley et al. "
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation."
Sci Transl Med 8, no. 369 (2016): 369ra175.