Title | Differences in race, molecular and tumor characteristics among women diagnosed with invasive ductal and lobular breast carcinomas. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Williams, Lindsay A., Katherine A. Hoadley, Hazel B. Nichols, Joseph Geradts, Charles M. Perou, Michael I. Love, Andrew F. Olshan, and Melissa A. Troester |
Journal | Cancer Causes Control |
Volume | 30 |
Issue | 1 |
Pagination | 31-39 |
Date Published | 2019 Jan |
ISSN | 1573-7225 |
Keywords | Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Female, Humans, Immunohistochemistry, Middle Aged, Racial Groups |
Abstract | BACKGROUND: The dominant invasive breast cancer histologic subtype, ductal carcinoma, shows intrinsic subtype diversity. However, lobular breast cancers are predominantly Luminal A. Both histologic subtypes show distinct relationships with patient and tumor characteristics, but it is unclear if these associations remain after accounting for intrinsic subtype.METHODS: Generalized linear models were used to estimate relative frequency differences (RFDs) and 95% confidence intervals (95% CIs) for the associations between age, race, tumor characteristics, immunohistochemistry (IHC) and RNA-based intrinsic subtype, TP53 status, and histologic subtype in the Carolina Breast Cancer Study (CBCS, n = 3,182) and The Cancer Genome Atlas (TCGA, n = 808).RESULTS: Relative to ductal tumors, lobular tumors were significantly more likely to be Luminal A [CBCS RNA RFD: 44.9%, 95% CI (39.6, 50.1); TCGA: RFD: 50.5%, 95% CI (43.9, 57.1)], were less frequent among young (≤ 50 years) and black women, were larger in size, low grade, less frequently had TP53 pathway defects, and were diagnosed at later stages. These associations persisted among Luminal A tumors (n = 242).CONCLUSIONS: While histology is strongly associated with molecular characteristics, histologic associations with age, race, size, grade, and stage persisted after restricting to Luminal A subtype. Histology may continue to be clinically relevant among Luminal A breast cancers. |
DOI | 10.1007/s10552-018-1121-1 |
Alternate Journal | Cancer Causes Control |
Original Publication | Differences in race, molecular and tumor characteristics among women diagnosed with invasive ductal and lobular breast carcinomas. |
PubMed ID | 30617775 |
PubMed Central ID | PMC6396692 |
Grant List | U01 CA179715 / CA / NCI NIH HHS / United States U54 CA156733 / CA / NCI NIH HHS / United States P30 ES010126 / ES / NIEHS NIH HHS / United States CCR16376756 / / Susan G. Komen / United States P50 CA058223 / CA / NCI NIH HHS / United States R01 HG009125 / HG / NHGRI NIH HHS / United States R01 CA195740 / CA / NCI NIH HHS / United States P01 CA142538 / CA / NCI NIH HHS / United States |