Publications

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Alzheimer Disease
Liu, Leo Yu- Feng, Yufeng Liu, and Hongtu Zhu. "SMAC: Spatial multi-category angle-based classifier for high-dimensional neuroimaging data." Neuroimage 175 (2018): 230-245.
Lu, Zhao-Hua, Zakaria Khondker, Joseph G. Ibrahim, Yue Wang, and Hongtu Zhu. "Bayesian longitudinal low-rank regression models for imaging genetic data from longitudinal studies." Neuroimage 149 (2017): 305-322.
Skup, Martha, Hongtu Zhu, and Heping Zhang. "Multiscale adaptive marginal analysis of longitudinal neuroimaging data with time-varying covariates." Biometrics 68, no. 4 (2012): 1083-92.
Chen, Tianle, Donglin Zeng, and Yuanjia Wang. "Multiple kernel learning with random effects for predicting longitudinal outcomes and data integration." Biometrics 71, no. 4 (2015): 918-28.
Kong, Dehan, Joseph G. Ibrahim, Eunjee Lee, and Hongtu Zhu. "FLCRM: Functional linear cox regression model." Biometrics 74, no. 1 (2018): 109-117.
Zhou, Fan, Haibo Zhou, Tengfei Li, and Hongtu Zhu. "Analysis of secondary phenotypes in multigroup association studies." Biometrics 76, no. 2 (2020): 606-618.
Kong, Dehan, Kelly S. Giovanello, Yalin Wang, Weili Lin, Eunjee Lee, Yong Fan, Murali P Doraiswamy, and Hongtu Zhu. "Predicting Alzheimer's Disease Using Combined Imaging-Whole Genome SNP Data." J Alzheimers Dis 46, no. 3 (2015): 695-702.
Skup, Martha, Hongtu Zhu, Yaping Wang, Kelly S. Giovanello, Ja-an Lin, Dinggang Shen, Feng Shi, Wei Gao, Weili Lin, Yong Fan et al. "Sex differences in grey matter atrophy patterns among AD and aMCI patients: results from ADNI." Neuroimage 56, no. 3 (2011): 890-906.
Algorithms
Lachos, Victor H., Larissa A. Matos, Luis M. Castro, and Ming-Hui Chen. "Flexible longitudinal linear mixed models for multiple censored responses data." Stat Med 38, no. 6 (2019): 1074-1102.
Koehler, Megan L., Howard D. Bondell, and Jung-Ying Tzeng. "Evaluating haplotype effects in case-control studies via penalized-likelihood approaches: prospective or retrospective analysis?" Genet Epidemiol 34, no. 8 (2010): 892-911.
Lin, Jiaxing, Jeremy Gresham, Tongrong Wang, So Young Kim, James Alvarez, Jeffrey S. Damrauer, Scott Floyd, Joshua Granek, Andrew Allen, Cliburn Chan et al. "bcSeq: an R package for fast sequence mapping in high-throughput shRNA and CRISPR screens." Bioinformatics 34, no. 20 (2018): 3581-3583.
Chen, Yasheng, Songbai Ji, Xunlei Wu, Hongyu An, Hongtu Zhu, Dinggang Shen, and Weili Lin. "Simulation of brain mass effect with an arbitrary Lagrangian and Eulerian FEM." Med Image Comput Comput Assist Interv 13, no. Pt 2 (2010): 274-81.
Li, Yimei, John H. Gilmore, Jiaping Wang, Martin Styner, Weili Lin, and Hongtu Zhu. "TwinMARM: two-stage multiscale adaptive regression methods for twin neuroimaging data." IEEE Trans Med Imaging 31, no. 5 (2012): 1100-12.
Chen, Yasheng, Hongyu An, Hongtu Zhu, Valerie Jewells, Diane Armao, Dinggang Shen, John H. Gilmore, and Weili Lin. "Longitudinal regression analysis of spatial-temporal growth patterns of geometrical diffusion measures in early postnatal brain development with diffusion tensor imaging." Neuroimage 58, no. 4 (2011): 993-1005.
Ma, Shuangge, Michael R. Kosorok, Jian Huang, and Ying Dai. "Incorporating higher-order representative features improves prediction in network-based cancer prognosis analysis." BMC Med Genomics 4 (2011): 5.
Kong, Dehan, Arnab Maity, Fang-Chi Hsu, and Jung-Ying Tzeng. "Testing and estimation in marker-set association study using semiparametric quantile regression kernel machine." Biometrics 72, no. 2 (2016): 364-71.
Zhu, Ruoqing, Ying-Qi Zhao, Guanhua Chen, Shuangge Ma, and Hongyu Zhao. "Greedy outcome weighted tree learning of optimal personalized treatment rules." Biometrics 73, no. 2 (2017): 391-400.
Ibrahim, Joseph G., Ming-Hui Chen, Amy H Xia, and Thomas Liu. "Bayesian meta-experimental design: evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes." Biometrics 68, no. 2 (2012): 578-86.
Skup, Martha, Hongtu Zhu, and Heping Zhang. "Multiscale adaptive marginal analysis of longitudinal neuroimaging data with time-varying covariates." Biometrics 68, no. 4 (2012): 1083-92.
Wang, Zhi, Arnab Maity, Chuhsing Kate Hsiao, Deepak Voora, Rima Kaddurah-Daouk, and Jung-Ying Tzeng. "Module-based association analysis for omics data with network structure." PLoS One 10, no. 3 (2015): e0122309.
Lee, Mei-Hsien, Jung-Ying Tzeng, Su-Yun Huang, and Chuhsing Kate Hsiao. "Combining an evolution-guided clustering algorithm and haplotype-based LRT in family association studies." BMC Genet 12 (2011): 48.
Pang, Herbert, Stephen L. George, Ken Hui, and Tiejun Tong. "Gene selection using iterative feature elimination random forests for survival outcomes." IEEE/ACM Trans Comput Biol Bioinform 9, no. 5 (2012): 1422-31.
Ni, Ai, and Jianwen Cai. "A regularized variable selection procedure in additive hazards model with stratified case-cohort design." Lifetime Data Anal 24, no. 3 (2018): 443-463.
Yazdani, Azam, Akram Yazdani, Sarah H. Elsea, Daniel J. Schaid, Michael R. Kosorok, Gita Dangol, and Ahmad Samiei. "Genome analysis and pleiotropy assessment using causal networks with loss of function mutation and metabolomics." BMC Genomics 20, no. 1 (2019): 395.
Laber, Eric B., Daniel J. Lizotte, and Bradley Ferguson. "Set-valued dynamic treatment regimes for competing outcomes." Biometrics 70, no. 1 (2014): 53-61.
Wang, Rujin, Dan-Yu Lin, and Yuchao Jiang. "SCOPE: A Normalization and Copy-Number Estimation Method for Single-Cell DNA Sequencing." Cell Syst 10, no. 5 (2020): 445-452.e6.
Yu, Fang, Ming-Hui Chen, Lynn Kuo, Heather Talbott, and John S. Davis. "Confident difference criterion: a new Bayesian differentially expressed gene selection algorithm with applications." BMC Bioinformatics 16 (2015): 245.
Marceau, Rachel, Wenbin Lu, Shannon Holloway, Michèle M. Sale, Bradford B. Worrall, Stephen R. Williams, Fang-Chi Hsu, and Jung-Ying Tzeng. "A Fast Multiple-Kernel Method With Applications to Detect Gene-Environment Interaction." Genet Epidemiol 39, no. 6 (2015): 456-68.
Brucker, Amanda, Wenbin Lu, Rachel Marceau West, Qi-You Yu, Chuhsing Kate Hsiao, Tzu-Hung Hsiao, Ching-Heng Lin, Patrik K. E. Magnusson, Patrick F. Sullivan, Jin P. Szatkiewicz et al. "Association test using Copy Number Profile Curves (CONCUR) enhances power in rare copy number variant analysis." PLoS Comput Biol 16, no. 5 (2020): e1007797.
Wang, Xin, Michael P. Epstein, and Jung-Ying Tzeng. "Analysis of gene-gene interactions using gene-trait similarity regression." Hum Hered 78, no. 1 (2014): 17-26.
Song, Guochen, and Anastasia Ivanova. "Enrollment and Stopping Rules for Managing Toxicity Requiring Long Follow-Up in Phase II Oncology Trials." J Biopharm Stat 25, no. 6 (2015): 1206-14.
Thomas, Laine, Leonard Stefanski, and Marie Davidian. "A moment-adjusted imputation method for measurement error models." Biometrics 67, no. 4 (2011): 1461-70.
He, Kevin, Yanming Li, Ji Zhu, Hongliang Liu, Jeffrey E. Lee, Christopher I. Amos, Terry Hyslop, Jiashun Jin, Huazhen Lin, Qinyi Wei et al. "Component-wise gradient boosting and false discovery control in survival analysis with high-dimensional covariates." Bioinformatics 32, no. 1 (2016): 50-7.
Zhou, Jie, Jiajia Zhang, Alexander C. Mclain, Wenbin Lu, Xuemei Sui, and James W. Hardin. "A varying-coefficient generalized odds rate model with time-varying exposure: An application to fitness and cardiovascular disease mortality." Biometrics 75, no. 3 (2019): 853-863.
Liu, Leo Yu- Feng, Yufeng Liu, and Hongtu Zhu. "SMAC: Spatial multi-category angle-based classifier for high-dimensional neuroimaging data." Neuroimage 175 (2018): 230-245.
Zhang, Xiang, Shunping Huang, Fei Zou, and Wei Wang. "TEAM: efficient two-locus epistasis tests in human genome-wide association study." Bioinformatics 26, no. 12 (2010): i217-27.
May, Ryan C., Joseph G. Ibrahim, and Haitao Chu. "Maximum likelihood estimation in generalized linear models with multiple covariates subject to detection limits." Stat Med 30, no. 20 (2011): 2551-61.
Li, Yimei, John H. Gilmore, Dinggang Shen, Martin Styner, Weili Lin, and Hongtu Zhu. "Multiscale adaptive generalized estimating equations for longitudinal neuroimaging data." Neuroimage 72 (2013): 91-105.
Zhao, Guolin, Rachel Marceau, Daowen Zhang, and Jung-Ying Tzeng. "Assessing gene-environment interactions for common and rare variants with binary traits using gene-trait similarity regression." Genetics 199, no. 3 (2015): 695-710.
Srivastava, Avi, Laraib Malik, Hirak Sarkar, Mohsen Zakeri, Fatemeh Almodaresi, Charlotte Soneson, Michael I. Love, Carl Kingsford, and Rob Patro. "Alignment and mapping methodology influence transcript abundance estimation." Genome Biol 21, no. 1 (2020): 239.
Zhang, Xiang, Shunping Huang, Wei Sun, and Wei Wang. "Rapid and robust resampling-based multiple-testing correction with application in a genome-wide expression quantitative trait loci study." Genetics 190, no. 4 (2012): 1511-20.
Sohn, Insuk, Kouros Owzar, Stephen L. George, Sujong Kim, and Sin-Ho Jung. "Robust test method for time-course microarray experiments." BMC Bioinformatics 11 (2010): 391.
Wu, Yuan, Christina D. Chambers, and Ronghui Xu. "Semiparametric sieve maximum likelihood estimation under cure model with partly interval censored and left truncated data for application to spontaneous abortion." Lifetime Data Anal 25, no. 3 (2019): 507-528.
Zhou, Jie, Jiajia Zhang, and Wenbin Lu. "An Expectation Maximization algorithm for fitting the generalized odds-rate model to interval censored data." Stat Med 36, no. 7 (2017): 1157-1171.
Psioda, Matthew A., and Joseph G. Ibrahim. "Bayesian design of a survival trial with a cured fraction using historical data." Stat Med 37, no. 26 (2018): 3814-3831.
Huang, Chao, Liang Shan, Cecil H Charles, Wolfgang Wirth, Marc Niethammer, and Hongtu Zhu. "Diseased Region Detection of Longitudinal Knee Magnetic Resonance Imaging Data." IEEE Trans Med Imaging 34, no. 9 (2015): 1914-27.
Kass, Robert E., Brian S. Caffo, Marie Davidian, Xiao-Li Meng, Bin Yu, and Nancy Reid. "Ten Simple Rules for Effective Statistical Practice." PLoS Comput Biol 12, no. 6 (2016): e1004961.
Kwak, Minjung, and Sin-Ho Jung. "Phase II clinical trials with time-to-event endpoints: optimal two-stage designs with one-sample log-rank test." Stat Med 33, no. 12 (2014): 2004-16.
Yuan, Ying, John H. Gilmore, Xiujuan Geng, Martin A. Styner, Kehui Chen, Jane-ling Wang, and Hongtu Zhu. "A longitudinal functional analysis framework for analysis of white matter tract statistics." Inf Process Med Imaging 23 (2013): 220-31.
Chen, Ming-Hui, Joseph G. Ibrahim, Amy H Xia, Thomas Liu, and Violeta Hennessey. "Bayesian sequential meta-analysis design in evaluating cardiovascular risk in a new antidiabetic drug development program." Stat Med 33, no. 9 (2014): 1600-18.
Wang, Wenjie, Ming-Hui Chen, Sy Han Chiou, Hui-Chuan Lai, Xiaojing Wang, Jun Yan, and Zhumin Zhang. "Onset of persistent pseudomonas aeruginosa infection in children with cystic fibrosis with interval censored data." BMC Med Res Methodol 16, no. 1 (2016): 122.
Love, Michael I., Charlotte Soneson, Peter F. Hickey, Lisa K. Johnson, Tessa N Pierce, Lori Shepherd, Martin Morgan, and Rob Patro. "Tximeta: Reference sequence checksums for provenance identification in RNA-seq." PLoS Comput Biol 16, no. 2 (2020): e1007664.
Zhu, Hongtu, Linglong Kong, Runze Li, Martin Styner, Guido Gerig, Weili Lin, and John H. Gilmore. "FADTTS: functional analysis of diffusion tensor tract statistics." Neuroimage 56, no. 3 (2011): 1412-25.
Chen, Tianle, Donglin Zeng, and Yuanjia Wang. "Multiple kernel learning with random effects for predicting longitudinal outcomes and data integration." Biometrics 71, no. 4 (2015): 918-28.
Xue, Hongqi, Shuang Wu, Yichao Wu, Juan C. Ramirez Idarraga, and Hulin Wu. "Independence screening for high dimensional nonlinear additive ODE models with applications to dynamic gene regulatory networks." Stat Med 37, no. 17 (2018): 2630-2644.
Hu, Y J., and D Y. Lin. "Analysis of untyped SNPs: maximum likelihood and imputation methods." Genet Epidemiol 34, no. 8 (2010): 803-15.
Liu, Ying, Yuanjia Wang, Michael R. Kosorok, Yingqi Zhao, and Donglin Zeng. "Augmented outcome-weighted learning for estimating optimal dynamic treatment regimens." Stat Med 37, no. 26 (2018): 3776-3788.
Jia, Xiaoyu, Anastasia Ivanova, and Shing M. Lee. "Selection of the initial design for the two-stage continual reassessment method." J Biopharm Stat 27, no. 3 (2017): 495-506.
Amorim, Leila D. A. F., and Jianwen Cai. "Modelling recurrent events: a tutorial for analysis in epidemiology." Int J Epidemiol 44, no. 1 (2015): 324-33.
Zhang, Min, Anastasios A. Tsiatis, Marie Davidian, Karen S. Pieper, and Kenneth W. Mahaffey. "Inference on treatment effects from a randomized clinical trial in the presence of premature treatment discontinuation: the SYNERGY trial." Biostatistics 12, no. 2 (2011): 258-69.
Chen, Qingxia, Ming-Hui Chen, David Ohlssen, and Joseph G. Ibrahim. "Bayesian modeling and inference for clinical trials with partial retrieved data following dropout." Stat Med 32, no. 24 (2013): 4180-95.
Zhu, Hongtu, Martin Styner, Yimei Li, Linglong Kong, Yundi Shi, Weili Lin, Christopher Coe, and John H. Gilmore. "Multivariate varying coefficient models for DTI tract statistics." Med Image Comput Comput Assist Interv 13, no. Pt 1 (2010): 690-7.
Lin, Ja-an, Hongtu Zhu, Ahn Mihye, Wei Sun, and Joseph G. Ibrahim. "Functional-mixed effects models for candidate genetic mapping in imaging genetic studies." Genet Epidemiol 38, no. 8 (2014): 680-91.
Xiao, W, H H. Zhang, and W Lu. "Robust regression for optimal individualized treatment rules." Stat Med 38, no. 11 (2019): 2059-2073.
Pang, Herbert, Keita Ebisu, Emi Watanabe, Laura Y. Sue, and Tiejun Tong. "Analysing breast cancer microarrays from African Americans using shrinkage-based discriminant analysis." Hum Genomics 5, no. 1 (2010): 5-16.
Gao, Fei, Jun Dong, Donglin Zeng, Alan Rong, and Joseph G. Ibrahim. "Pattern mixture models for clinical validation of biomarkers in the presence of missing data." Stat Med 36, no. 19 (2017): 2994-3004.
Zhang, Yuanye, Ming-Hui Chen, Joseph G. Ibrahim, Donglin Zeng, Qingxia Chen, Zhiying Pan, and Xiaodong Xue. "Bayesian gamma frailty models for survival data with semi-competing risks and treatment switching." Lifetime Data Anal 20, no. 1 (2014): 76-105.
Guo, Ruixin, Hongtu Zhu, Sy-Miin Chow, and Joseph G. Ibrahim. "Bayesian lasso for semiparametric structural equation models." Biometrics 68, no. 2 (2012): 567-77.
Choi, Jaeun, Donglin Zeng, Andrew F. Olshan, and Jianwen Cai. "Joint modeling of survival time and longitudinal outcomes with flexible random effects." Lifetime Data Anal 24, no. 1 (2018): 126-152.
Yu, Jichang, Haibo Zhou, and Jianwen Cai. "Accelerated failure time model for data from outcome-dependent sampling." Lifetime Data Anal 27, no. 1 (2021): 15-37.
Diao, Guoqing, Jun Dong, Donglin Zeng, Chunlei Ke, Alan Rong, and Joseph G. Ibrahim. "Biomarker threshold adaptive designs for survival endpoints." J Biopharm Stat 28, no. 6 (2018): 1038-1054.
Huang, Chao, Liang Shan, Cecil Charles, Marc Niethammer, and Hongtu Zhu. "Diseased region detection of longitudinal knee MRI data." Inf Process Med Imaging 23 (2013): 632-43.
Gao, Wei, Hongtu Zhu, Kelly Giovanello, and Weili Lin. "Multivariate network-level approach to detect interactions between large-scale functional systems." Med Image Comput Comput Assist Interv 13, no. Pt 2 (2010): 298-305.
Wang, WeiBo, Wei Wang, Wei Sun, James J. Crowley, and Jin P. Szatkiewicz. "Allele-specific copy-number discovery from whole-genome and whole-exome sequencing." Nucleic Acids Res 43, no. 14 (2015): e90.
Gao, Fei, Donglin Zeng, and Dan-Yu Lin. "Semiparametric regression analysis of interval-censored data with informative dropout." Biometrics 74, no. 4 (2018): 1213-1222.
Hung, Hung, Yu-Ting Lin, Penweng Chen, Chen-Chien Wang, Su-Yun Huang, and Jung-Ying Tzeng. "Detection of gene-gene interactions using multistage sparse and low-rank regression." Biometrics 72, no. 1 (2016): 85-94.
Hu, Y J., D Y. Lin, and D Zeng. "A general framework for studying genetic effects and gene-environment interactions with missing data." Biostatistics 11, no. 4 (2010): 583-98.
Lin, Jiaxing, Alexander Sibley, Ivo Shterev, Andrew Nixon, Federico Innocenti, Cliburn Chan, and Kouros Owzar. "fastJT: An R package for robust and efficient feature selection for machine learning and genome-wide association studies." BMC Bioinformatics 20, no. 1 (2019): 333.
Kang, Suhyun, Wenbin Lu, and Mengling Liu. "Efficient estimation for accelerated failure time model under case-cohort and nested case-control sampling." Biometrics 73, no. 1 (2017): 114-123.
Shin, Seung Jun, Yichao Wu, Hao Helen Zhang, and Yufeng Liu. "Probability-enhanced sufficient dimension reduction for binary classification." Biometrics 70, no. 3 (2014): 546-55.
Yuan, Ying, John H. Gilmore, Xiujuan Geng, Styner Martin, Kehui Chen, Jane-ling Wang, and Hongtu Zhu. "FMEM: functional mixed effects modeling for the analysis of longitudinal white matter Tract data." Neuroimage 84 (2014): 753-64.
Hua, Zhaowei, David B. Dunson, John H. Gilmore, Martin A. Styner, and Hongtu Zhu. "Semiparametric Bayesian local functional models for diffusion tensor tract statistics." Neuroimage 63, no. 1 (2012): 460-74.
Yan, Kang K., Xiaofei Wang, Wendy W. T. Lam, Varut Vardhanabhuti, Anne W. M. Lee, and Herbert H. Pang. "Radiomics analysis using stability selection supervised component analysis for right-censored survival data." Comput Biol Med 124 (2020): 103959.
Yuan, Shuai, Hao Helen Zhang, and Marie Davidian. "Variable selection for covariate-adjusted semiparametric inference in randomized clinical trials." Stat Med 31, no. 29 (2012): 3789-804.

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